The Shahmoradian lab at the UT Southwestern (UTSW) Medical Center O’Donnell Brain Institute, Center for Alzheimer’s and Neurodegenerative Diseases in Dallas, Texas, is seeking a full-time Postdoctoral Scientist to apply cellular structural biology techniques and complementary methods to investigate the macromolecular basis of protein aggregation and membrane remodelling in neurons and mammalian tissues.

Main methods are cryo-focused ion beam specimen preparations, cryo-electron tomography and 3D processing/sub-tomogram averaging, together with correlative light/electron microscopy and optogenetics/advanced labeling approaches.


  • Ph.D. in life science or engineering (or due to complete within 6 months)
  • Demonstrated ability to have worked independently and in a team
  • Track record with original contributions
  • Prior experience with successfully operating high-tech microscopy instrumentation and computational processing techniques
  • Programming and machine learning experience is a plus

Working environment: 

Successful candidates will benefit from excellent infrastructure and growing resources available here at UTSW:

  • Newly purchased Thermo Fisher Aquilos II cryoFIB/SEM equipped with both internal cryo-widefield and external Leica cryo-confocal fluorescence microscopes
  • 2 Titan Krios cryo-electron microscopes with direct electron detectors, including one with the latest generation cold field emission gun and Selectris-X energy filter (other has Volta phase plate and BioQuantum energy filter)
  • Talos Arctica cryo-electron microscope with K3 direct electron detector and Volta phase plate
  • Talos Glacios cryo-electron microscope with Falcon direct electron detector and Ceta-D camera
  • Custom-engineered, super-resolution, light-sheet and cleared tissue microscopes
  • UTSW Whole Brain Microscopy Facility with several high-throughput microscopes including two state-of-the-art multi-photon microscopes with integrated precision vibratomes
  • UTSW Green Center for Systems Biology with ~25 isolated microscope development bays equipped with optical tables

UTSW Department of Bioinformatics with BioHPC, ahigh-performance computing and storage facility equipped with ~1000 CPU and~120 GPU nodes connected to 50 PB of storage for in-house data analysis (Allinstruments have direct mounts to this computing infrastructure) 

University highlights: 

  • Highly collaborative and inclusive environment encompassing the entire spectrum of basic, translational, and clinical research
  • Six Nobel Prize Winners and 25 members of the National Academy of Sciences
  • Ranked No. 1 in the world among healthcare institutions in biomedical sciences (Nature Index 2019)
  • Several employee benefits including free health insurance for full-time staff, and excellent coverage for dependents.

Living environment: 

The Dallas-Fort Worth Metroplex is home to:

  • Top educational school systems in Texas and the nation
  • Dallas Arts District, the largest contiguous urban arts district in the United States, covering contiguous ~120 acres (0.5 square kilometer)
  • “Deep Ellum”, the live music capital of North Texas and a hub for the performing arts from theater to comedy
  • Several parks and lakes great for boating and camping
  • Multitude of great dining and shopping options
  • Central location in the US, with easy access to major international airport and a smaller national airport

To apply, please complete the form below. Please include the names and contact details of 3 professional references.

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